Quick Verdict: RxSure vs SignatureRx
SignatureRx is a pay-per-prescription e-prescribing tool (£1+VAT per Rx) for generating private prescriptions digitally. RxSure is an all-in-one platform covering the complete patient journey — booking, SmPC-guided consultations, prescription generation, integrated payments, and GPhC/CQC compliance — for a flat monthly fee.
Choose SignatureRx if you only need to generate electronic prescriptions and issue fewer than 50 per month.
Choose RxSure if you want one platform to handle booking, consultations, prescriptions, payments, and compliance — especially if you plan to grow.
What Is SignatureRx?
SignatureRx is a UK-based private prescription software that allows prescribers to generate electronic private prescriptions. It uses a pay-per-prescription pricing model at £1+VAT per prescription, making it a variable-cost option for practitioners issuing private prescriptions. SignatureRx currently ranks well in Google for “private prescription software” due to strong keyword-matched page titles and SEO.
However, SignatureRx focuses specifically on the prescription generation step. It does not include patient booking, clinical consultation workflows, payment processing, compliance management, or multi-site capabilities.
What Is RxSure?
RxSure is an all-in-one private prescription software platform built for UK pharmacies, clinics, and independent prescribers. It covers the complete private prescribing workflow — from online patient booking and pre-screening through SmPC-guided clinical consultations, electronic prescription generation, integrated payment processing, and GPhC/CQC compliance management.
RxSure charges a flat monthly subscription with no per-prescription fees and zero platform fees on patient payments.
Feature Comparison: RxSure vs SignatureRx
| Feature | RxSure | SignatureRx |
|---|---|---|
| Private Prescription Generation | ✓ | ✓ |
| Online Patient Booking | ✓ | ✗ |
| SmPC-Guided Consultations | ✓ | ✗ |
| Pre-Screening Questionnaires | ✓ | ✗ |
| Integrated Payment Processing | ✓ | ✗ |
| Multi-Site Management | ✓ | ✗ |
| Staff Training & CPD Tracking | ✓ | ✗ |
| Video Consultations | ✓ | ✗ |
| AI Clinical Support | ✓ | ✗ |
| GPhC + CQC Compliance Dashboard | ✓ | Partial |
| GP Notification Letters | ✓ | ✓ |
Pricing: RxSure vs SignatureRx
RxSure
- Standard: £60/month (free for 3 months)
- Pro: £100/month
- Per-prescription fee: None
- Platform fee on payments: None
- Cost at 100 Rx/month: £60-100
SignatureRx
- Per prescription: £1 + VAT (£1.20)
- Monthly subscription: None
- Cost at 50 Rx/month: £60
- Cost at 100 Rx/month: £120
- Cost at 200 Rx/month: £240
The economics are clear: SignatureRx is cheaper below ~50 prescriptions per month. Above that, RxSure’s flat fee delivers significantly more value — and includes booking, consultations, payments, and compliance that SignatureRx doesn’t offer at any price.
Key Differences
1. Prescribing Only vs Complete Platform
SignatureRx generates electronic prescriptions. That’s its core function. RxSure manages the entire patient journey: online booking, pre-screening questionnaires, SmPC-guided clinical consultation, prescription generation, payment processing, GP notification, and compliance tracking. With SignatureRx, you need separate tools for booking, consultations, and payments. With RxSure, one platform replaces them all.
2. Per-Prescription vs Flat Fee
SignatureRx’s £1+VAT per prescription means costs scale linearly with volume. At 200 prescriptions per month, you’re paying £240/month for prescription generation alone — with no booking, consultations, or payments. RxSure’s flat fee means predictable costs regardless of volume, and you get the complete platform.
3. Clinical Safety
RxSure is the only private prescription software with SmPC-guided consultation templates. These embed contraindication checks, dosage guidance, and safety warnings directly into the consultation workflow. SignatureRx does not include clinical consultation workflows or SmPC-based safety checks — the clinical assessment happens outside the platform.
4. Scale & Multi-Site
SignatureRx is designed for individual prescribers. RxSure supports multi-site management — pharmacy groups and clinic chains can manage prescribing across all locations from one dashboard, with per-site branding, cross-site reporting, and centralised compliance.
Which Should You Choose?
Choose SignatureRx If…
- You only need electronic prescription generation
- You issue fewer than 50 prescriptions per month
- You already have booking and payment systems
- You don’t need consultation workflows
- You prefer pay-per-use over monthly subscriptions
Choose RxSure If…
- You want one platform for everything (booking → Rx → payment)
- You value SmPC-guided clinical safety
- You issue 50+ prescriptions per month
- You manage multiple pharmacy branches or clinics
- You need GPhC/CQC compliance management
- You want predictable flat-fee pricing
Frequently Asked Questions
How does RxSure compare to SignatureRx?
SignatureRx is a pay-per-prescription e-prescribing tool that charges £1+VAT per prescription. It focuses specifically on generating electronic private prescriptions. RxSure is an all-in-one platform that covers the complete patient journey — online booking, SmPC-guided consultations, prescription generation, integrated payment processing, and GPhC/CQC compliance management — all for a flat monthly fee with no per-prescription charges.
Is RxSure cheaper than SignatureRx?
It depends on your prescription volume. SignatureRx costs £1.20 per prescription (including VAT), so at 50 prescriptions per month you’d pay £60. At 100 prescriptions, that’s £120. RxSure’s Standard plan is £60/month regardless of volume — and includes booking, consultations, payments, and compliance that SignatureRx doesn’t offer at any price. For practices issuing 50+ prescriptions monthly, RxSure delivers significantly more value.
Does SignatureRx include patient booking or payments?
No. SignatureRx is focused on prescription generation only. It does not include online patient booking, pre-screening questionnaires, consultation workflows, or integrated payment processing. You would need to use separate third-party tools for these functions and manage them independently. RxSure includes all of these in one integrated platform.
Which platform is better for pharmacy groups with multiple sites?
RxSure. It includes multi-site management designed for pharmacy groups and clinic chains — with centralised compliance dashboards, cross-site reporting, per-site branding, and unified patient records across all locations. SignatureRx is designed primarily for individual prescribers and does not offer multi-site management capabilities.
Can I migrate from SignatureRx to RxSure?
Yes. RxSure offers a free 3-month trial so you can set up and test the full platform alongside your existing tools. Many practices find the transition straightforward because RxSure includes all of SignatureRx’s prescription generation features plus booking, consultations, payments, and compliance management. The RxSure team provides onboarding support to help you get started.
Does RxSure include SmPC-guided clinical safety features?
Yes. RxSure is the only private prescription software with SmPC-guided consultation templates built into the workflow. These templates embed contraindication checks, dosage guidance, and safety warnings directly into every consultation — ensuring that every prescription is backed by a documented, compliant clinical assessment. SignatureRx does not include consultation workflows or SmPC-based safety checks.
Explore more comparisons and platform details
